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The ongoing COVID-19 pandemic has pushed scientists and technologists to find novel strategies to develop new materials to prevent the transmission, spread, and entry of pathogens into the human body. In this report, the fabrication of polyvinyl chloride (PVC)-SiO2-Ag composite is presented, in which the percentage of Ag is 0.84% wt. Our findings render that this composite eliminates (> 99.8%) bacteria and fungus (Staphylococcus aureus, Escherichia coli, Penicillium funiculosum) and SARS-CoV-2, by surface contact in 2 h hours and 15 min, respectively. Specific migration analysis shown that the use of the PVC-SiO2-Ag composite is considered safe and effective for food preservation. This research and innovation front can be considered a breakthrough for the design of biocide materials. Future directions for this exciting and highly significant research field can open the door to the development of new technologies for the fabrication of packaging films to protect consumer products (such as fruits, vegetables, and other foods).